IKK Complex: Key Regulator of Inflammation and Immune Response

Target Name: I-kappa-B-kinase (IKK) complex

NCBI ID: P16704

I-kappa-B-kinase (IKK) complex

Other Name(s): IKK

IKK Complex: Key Regulator of Inflammation and Immune Response

I-kappa-B-kinase (IKK) complex is a protein that plays a crucial role in inflammation and immune responses. It is a complex that consists of the kinases IKK alpha, beta, and gamma, as well as their associated adapter protein p160 . The IKK complex is involved in the regulation of inflammation, inflammation-related pain, and autoimmune diseases.

IKK is a protein that is expressed in various tissues and cells throughout the body, including the brain, pancreas, heart, and blood cells. It is a key regulator of inflammation and immune responses, and its activity has been implicated in a wide range of diseases, including cancer, autoimmune diseases, and neurodegenerative disorders.

One of the functions of IKK is its role in the regulation of inflammation. Inflammation is a critical immune response that helps the body to heal from injuries and illnesses, but when inflammation becomes chronic or uncontrolled, it can lead to a range of diseases, including cancer and autoimmune disorders. IKK is involved in the regulation of the inflammatory response by controlling the activity of immune cells and promoting the production of anti-inflammatory cytokines.

IKK is also involved in the regulation of pain. Pain is a critical sense that helps the body to respond to injuries and illnesses, and pain can be a sign of underlying inflammation that needs to be addressed. IKK is involved in the regulation of pain by controlling the activity of immune cells and promoting the production of pain-sensitive chemicals.

IKK is also involved in the regulation of autoimmune diseases. Autoimmune diseases are a group of diseases that occur when the immune system attacks the body's own tissues, including the brain and other organs. of immune cells and promoting the production of autoimmune cytokines.

In addition to its role in inflammation and immune responses, IKK is also involved in the regulation of cell survival. IKK is a pro-survival protein that helps to protect cells from the effects of stress and damage, including reactive oxygen species (ROS). ROS are highly reactive molecules that can damage cells and contribute to a range of diseases, including cancer. IKK is involved in the regulation of cell survival by controlling the activity of cell stress pathways and promoting the production of anti-inflammatory cytokines.

IKK is also involved in the regulation of cellular signaling pathways. IKK is a signaling protein that is involved in a wide range of cellular signaling pathways, including the regulation of cell adhesion, migration, and the production of signaling molecules. IKK is also involved in the regulation of cellular signaling pathways by controlling the activity of protein kinase, including the serine/thionylate protein kinase (PTK) pathway.

In conclusion, I-kappa-B-kinase (IKK) complex is a protein that plays a crucial role in inflammation and immune responses. It is involved in the regulation of inflammation, pain, autoimmune diseases, and cell survival and signaling pathways. The IKK complex is a potential drug target and biomarker for a wide range of diseases, including cancer, autoimmune diseases, and neurodegenerative disorders. Further research is needed to fully understand the role of IKK in these diseases and to develop effective treatments.

Protein Name: I-kappa-B-kinase (IKK) Complex

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